SGSM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTPase activator with activity towards RAB32 and RAB33B, which are regulators of membrane trafficking. The encoded protein inactivates RAB32 and can bind RAB9A-GTP, a protein required for RAB32 activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.15279805
2synaptic vesicle maturation (GO:0016188)6.12248538
3locomotory exploration behavior (GO:0035641)5.85265450
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.62848314
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.43474878
6vocalization behavior (GO:0071625)5.16960923
7glutamate secretion (GO:0014047)5.14303650
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.13187886
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.06641023
10synaptic vesicle exocytosis (GO:0016079)4.93319191
11regulation of synaptic vesicle exocytosis (GO:2000300)4.87511039
12regulation of glutamate receptor signaling pathway (GO:1900449)4.85927696
13regulation of neuronal synaptic plasticity (GO:0048168)4.52173744
14layer formation in cerebral cortex (GO:0021819)4.47739527
15regulation of synapse structural plasticity (GO:0051823)4.46519577
16regulation of synaptic vesicle transport (GO:1902803)4.44029373
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.39040455
18dendritic spine morphogenesis (GO:0060997)4.38240707
19exploration behavior (GO:0035640)4.33471054
20protein localization to synapse (GO:0035418)4.27035095
21neurotransmitter secretion (GO:0007269)4.24539742
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.18913089
23mannose metabolic process (GO:0006013)4.11112744
24regulation of ARF GTPase activity (GO:0032312)4.02364494
25proline transport (GO:0015824)4.01518876
26neurotransmitter-gated ion channel clustering (GO:0072578)3.95815205
27activation of protein kinase A activity (GO:0034199)3.90555262
28synaptic transmission, glutamatergic (GO:0035249)3.83780798
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79057339
30negative regulation of erythrocyte differentiation (GO:0045647)3.78318878
31long-term memory (GO:0007616)3.77553482
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.73209370
33positive regulation of synaptic transmission, GABAergic (GO:0032230)3.70611505
34sodium ion export (GO:0071436)3.64305089
35neuromuscular process controlling balance (GO:0050885)3.63595992
36neuron cell-cell adhesion (GO:0007158)3.61812957
37neuronal action potential propagation (GO:0019227)3.61560136
38cellular potassium ion homeostasis (GO:0030007)3.59556171
39semaphorin-plexin signaling pathway (GO:0071526)3.57927767
40regulation of dendritic spine morphogenesis (GO:0061001)3.55113752
41auditory behavior (GO:0031223)3.53836307
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53524450
43glutamate receptor signaling pathway (GO:0007215)3.53352311
44gamma-aminobutyric acid transport (GO:0015812)3.51159417
45positive regulation of membrane potential (GO:0045838)3.49962825
46G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.47062763
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46730844
48neuron-neuron synaptic transmission (GO:0007270)3.46292724
49glycine transport (GO:0015816)3.44322844
50regulation of synaptic plasticity (GO:0048167)3.42911148
51response to auditory stimulus (GO:0010996)3.42655187
52positive regulation of synapse maturation (GO:0090129)3.41857193
53cell communication by electrical coupling (GO:0010644)3.41843888
54synaptic vesicle endocytosis (GO:0048488)3.39144476
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37979217
56cerebellar Purkinje cell layer development (GO:0021680)3.37398317
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36822614
58regulation of postsynaptic membrane potential (GO:0060078)3.34019999
59neurotransmitter transport (GO:0006836)3.33137353
60dendrite morphogenesis (GO:0048813)3.32342416
61cerebellar Purkinje cell differentiation (GO:0021702)3.23675581
62neuron recognition (GO:0008038)3.23103415
63neuronal ion channel clustering (GO:0045161)3.22855064
64dendritic spine organization (GO:0097061)3.22819163
65regulation of ARF protein signal transduction (GO:0032012)3.17797453
66regulation of neurotransmitter secretion (GO:0046928)3.17345734
67positive regulation of neurotransmitter secretion (GO:0001956)3.15054311
68regulation of vesicle fusion (GO:0031338)3.11866451
69positive regulation of neurotransmitter transport (GO:0051590)3.10409804
70prepulse inhibition (GO:0060134)3.10033040
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.09468475
72alanine transport (GO:0032328)3.08194294
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06963372
74transmission of nerve impulse (GO:0019226)3.06748306
75regulation of neurotransmitter levels (GO:0001505)3.06128744
76axonal fasciculation (GO:0007413)3.05693401
77positive regulation of dendritic spine development (GO:0060999)3.05500684
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.03025097
79positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.02726346
80membrane depolarization during action potential (GO:0086010)3.02413143
81cell-cell junction maintenance (GO:0045217)3.00207813
82neuromuscular process controlling posture (GO:0050884)2.99045573
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98105678
84long-term synaptic potentiation (GO:0060291)2.97025338
85regulation of neurotransmitter transport (GO:0051588)2.95943524
86postsynaptic membrane organization (GO:0001941)2.94961412
87establishment of nucleus localization (GO:0040023)2.94556841
88negative regulation of cell size (GO:0045792)2.92430410
89neuromuscular process (GO:0050905)2.91801469
90cell migration in hindbrain (GO:0021535)2.91695372
91membrane depolarization (GO:0051899)2.90986101
92cerebellar granule cell differentiation (GO:0021707)2.90778850
93peptidyl-tyrosine autophosphorylation (GO:0038083)2.89769629
94regulation of dendritic spine development (GO:0060998)2.89712085
95vesicle transport along microtubule (GO:0047496)2.87726102
96insulin-like growth factor receptor signaling pathway (GO:0048009)2.84969314
97positive regulation of synaptic transmission (GO:0050806)2.84535477
98innervation (GO:0060384)2.84365822
99membrane hyperpolarization (GO:0060081)2.83307167
100central nervous system projection neuron axonogenesis (GO:0021952)2.82838946
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.82659257
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81196087
103regulation of synaptic transmission (GO:0050804)2.81077693
104dopamine receptor signaling pathway (GO:0007212)2.79860171
105learning (GO:0007612)2.79703957
106striatum development (GO:0021756)2.79376262
107regulation of calcium ion-dependent exocytosis (GO:0017158)2.78812824
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.78765359
109behavioral fear response (GO:0001662)2.77388701
110behavioral defense response (GO:0002209)2.77388701
111positive regulation of Rap GTPase activity (GO:0032854)2.76601390
112L-amino acid import (GO:0043092)2.76127940
113cellular sodium ion homeostasis (GO:0006883)2.74589770
114regulation of synapse maturation (GO:0090128)2.67830828
115negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.65638569
116endothelial cell chemotaxis (GO:0035767)2.63067567
117positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.58767007
118signal complex assembly (GO:0007172)2.56254923
119adherens junction assembly (GO:0034333)2.51502280
120regulation of histone H3-K27 methylation (GO:0061085)2.51234490
121activation of JUN kinase activity (GO:0007257)2.50829048
122amino acid import (GO:0043090)2.50605257
123planar cell polarity pathway involved in neural tube closure (GO:0090179)2.48838211
124positive regulation of histone deacetylation (GO:0031065)2.44749593
125regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.43387948
126regulation of extracellular matrix disassembly (GO:0010715)2.42105817
127regulation of Rap GTPase activity (GO:0032317)2.39504525
128histone H3-K9 demethylation (GO:0033169)2.37875746
129histone H4 deacetylation (GO:0070933)2.37573507
130mitochondrion transport along microtubule (GO:0047497)2.37515723
131establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.37515723
132regulation of NFAT protein import into nucleus (GO:0051532)2.37425068
133positive regulation of CREB transcription factor activity (GO:0032793)2.36219641
134thymic T cell selection (GO:0045061)2.36086696
135cell-substrate adherens junction assembly (GO:0007045)2.32590681
136focal adhesion assembly (GO:0048041)2.32590681
137positive regulation of protein dephosphorylation (GO:0035307)2.32462428
138cell volume homeostasis (GO:0006884)2.29921619
139activation of Rac GTPase activity (GO:0032863)2.29032816
140chondroitin sulfate catabolic process (GO:0030207)2.28166541
141negative regulation of Ras protein signal transduction (GO:0046580)2.26306564
142establishment of mitochondrion localization (GO:0051654)2.25585047
143activation of MAPKKK activity (GO:0000185)2.24492718
144cell junction maintenance (GO:0034331)2.23678390
145histone H3 deacetylation (GO:0070932)2.22582065
146cellular response to catecholamine stimulus (GO:0071870)2.20143576
147cellular response to monoamine stimulus (GO:0071868)2.20143576
148regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.18971739
149ear development (GO:0043583)2.15393405
150negative regulation of small GTPase mediated signal transduction (GO:0051058)2.14846473
151negative regulation of fatty acid transport (GO:2000192)2.13125663
152cAMP biosynthetic process (GO:0006171)2.11402593
153protein targeting to plasma membrane (GO:0072661)2.11338780
154cellular response to prostaglandin stimulus (GO:0071379)2.09456098
155apoptotic process involved in morphogenesis (GO:0060561)2.07935019
156camera-type eye morphogenesis (GO:0048593)2.06343773
157positive regulation of Rac GTPase activity (GO:0032855)2.03897033
158response to muramyl dipeptide (GO:0032495)2.03094928
159regulation of Ras protein signal transduction (GO:0046578)2.03018727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.92451470
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.60992328
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.92814541
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86926884
5DROSHA_22980978_ChIP-Seq_HELA_Human2.76276667
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74873512
7GBX2_23144817_ChIP-Seq_PC3_Human2.72136209
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71443848
9REST_21632747_ChIP-Seq_MESCs_Mouse2.65577789
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57895141
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57895141
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.57533143
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50688836
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48505403
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41951219
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35583366
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35442622
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.33117130
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.29707233
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.28915016
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26718492
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26513194
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26356729
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.25755374
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25602826
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.23999234
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.22767012
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.16969573
29TCF7_22412390_ChIP-Seq_EML_Mouse2.14808128
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12834173
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06798543
32VDR_21846776_ChIP-Seq_THP-1_Human2.03359093
33ELK3_25401928_ChIP-Seq_HUVEC_Human2.01138501
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.98128284
35RACK7_27058665_Chip-Seq_MCF-7_Human1.93078762
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87652059
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84303752
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83376237
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79634510
40MYC_22102868_ChIP-Seq_BL_Human1.77217848
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.72379772
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70282514
43* P68_20966046_ChIP-Seq_HELA_Human1.67969245
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62731351
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62605949
46CREB1_26743006_Chip-Seq_LNCaP_Human1.57708846
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55535318
48KDM2B_26808549_Chip-Seq_K562_Human1.54988925
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52479501
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.49734941
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47404180
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47327199
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46755599
54AR_21572438_ChIP-Seq_LNCaP_Human1.46208198
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45346460
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.45317755
57* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43374920
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42849673
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42630732
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42534883
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.39164245
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36842863
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.36385237
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32746291
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32743503
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29746582
67AR_19668381_ChIP-Seq_PC3_Human1.26416562
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26023538
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25359765
70* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24891804
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24637935
72SMAD4_21799915_ChIP-Seq_A2780_Human1.24582510
73ZNF274_21170338_ChIP-Seq_K562_Hela1.24056519
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.23810055
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.23257297
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23239541
77* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21745811
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20179393
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.19832600
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17234132
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17053916
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16511076
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16259939
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15006412
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14710988
86TP63_22573176_ChIP-Seq_HFKS_Human1.14557473
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.14199807
88* ELF1_20517297_ChIP-Seq_JURKAT_Human1.11236308
89MAF_26560356_Chip-Seq_TH2_Human1.11223380
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09786953
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09390756
92VDR_24763502_ChIP-Seq_THP-1_Human1.09020239
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08811253
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08262259
95CTCF_27219007_Chip-Seq_Bcells_Human1.07526535
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07435543
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07205172
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06060550
99STAT3_23295773_ChIP-Seq_U87_Human1.05950301
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04843350
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04677491
102* OCT4_19829295_ChIP-Seq_ESCs_Human1.04533686
103* BCOR_27268052_Chip-Seq_Bcells_Human1.04450436
104TP53_22127205_ChIP-Seq_IMR90_Human1.03915368
105MAF_26560356_Chip-Seq_TH1_Human1.03807532
106* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02464250
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02059450
108* TP53_23651856_ChIP-Seq_MEFs_Mouse1.02005247
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01402328
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.01032990
111* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00762674
112UTX_26944678_Chip-Seq_JUKART_Human1.00015841
113AHR_22903824_ChIP-Seq_MCF-7_Human0.99649909
114SMAD3_21741376_ChIP-Seq_EPCs_Human0.99638648
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.99578098
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99349131
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98997428
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98608762
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98592689
120AR_25329375_ChIP-Seq_VCAP_Human0.96285546
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95649663
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95174660
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95076533
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.94953452
125* BCL6_27268052_Chip-Seq_Bcells_Human0.93096962
126* SMAD3_21741376_ChIP-Seq_ESCs_Human0.92964480
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92712192
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92566210
129LXR_22292898_ChIP-Seq_THP-1_Human0.92306166
130SA1_27219007_Chip-Seq_Bcells_Human0.92087601
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91465739
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91287963
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90647515
134* TCF4_23295773_ChIP-Seq_U87_Human0.88578910
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87495723
136KLF4_19829295_ChIP-Seq_ESCs_Human0.86130306
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85996579
138* SMC4_20622854_ChIP-Seq_HELA_Human0.85725938
139RNF2_27304074_Chip-Seq_NSC_Mouse0.85592127
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85310212
141CBX2_27304074_Chip-Seq_ESCs_Mouse0.84830686
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83639905
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.82130659
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.81504737
145KDM2B_26808549_Chip-Seq_JURKAT_Human0.81385926
146ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79097675
147KDM2B_26808549_Chip-Seq_DND41_Human0.78379593
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78016126
149TP53_16413492_ChIP-PET_HCT116_Human0.78014887
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.77351649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.12884109
2MP0003635_abnormal_synaptic_transmissio4.13650803
3MP0003880_abnormal_central_pattern3.86334215
4MP0004270_analgesia3.47304813
5MP0003705_abnormal_hypodermis_morpholog3.46787748
6MP0002822_catalepsy3.42845627
7MP0002063_abnormal_learning/memory/cond3.35959409
8MP0009745_abnormal_behavioral_response3.26462322
9MP0009780_abnormal_chondrocyte_physiolo2.95295066
10MP0002064_seizures2.90056506
11MP0005058_abnormal_lysosome_morphology2.78756525
12MP0002572_abnormal_emotion/affect_behav2.65147672
13MP0009046_muscle_twitch2.62946686
14MP0005423_abnormal_somatic_nervous2.62352310
15MP0001968_abnormal_touch/_nociception2.53557196
16MP0001849_ear_inflammation2.52540929
17MP0001486_abnormal_startle_reflex2.43654283
18MP0005409_darkened_coat_color2.43624980
19MP0002909_abnormal_adrenal_gland2.38046252
20MP0001348_abnormal_lacrimal_gland2.36640940
21MP0002734_abnormal_mechanical_nocicepti2.30160612
22MP0002272_abnormal_nervous_system2.18288059
23MP0004858_abnormal_nervous_system2.04731458
24MP0002735_abnormal_chemical_nociception2.01453823
25MP0001501_abnormal_sleep_pattern1.92550527
26MP0002733_abnormal_thermal_nociception1.91196183
27MP0001440_abnormal_grooming_behavior1.85672585
28MP0004811_abnormal_neuron_physiology1.85537297
29MP0002249_abnormal_larynx_morphology1.84639777
30MP0005076_abnormal_cell_differentiation1.84561741
31MP0003879_abnormal_hair_cell1.84532605
32MP0001958_emphysema1.81724788
33MP0001970_abnormal_pain_threshold1.81365737
34MP0008569_lethality_at_weaning1.80881415
35MP0002736_abnormal_nociception_after1.78114914
36MP0008961_abnormal_basal_metabolism1.77559937
37MP0003283_abnormal_digestive_organ1.76842479
38MP0008260_abnormal_autophagy1.75858860
39MP0000569_abnormal_digit_pigmentation1.75567761
40MP0002557_abnormal_social/conspecific_i1.74699138
41MP0000778_abnormal_nervous_system1.66337687
42MP0005646_abnormal_pituitary_gland1.64414116
43MP0003329_amyloid_beta_deposits1.64132226
44MP0002184_abnormal_innervation1.64100286
45MP0003122_maternal_imprinting1.64078448
46MP0009278_abnormal_bone_marrow1.59992440
47MP0000955_abnormal_spinal_cord1.59349026
48MP0003787_abnormal_imprinting1.58878612
49MP0002067_abnormal_sensory_capabilities1.58441591
50MP0005645_abnormal_hypothalamus_physiol1.57246415
51MP0003279_aneurysm1.52499623
52MP0003123_paternal_imprinting1.51743540
53MP0004885_abnormal_endolymph1.48293464
54MP0005386_behavior/neurological_phenoty1.46261075
55MP0004924_abnormal_behavior1.46261075
56MP0001984_abnormal_olfaction1.41553875
57MP0003303_peritoneal_inflammation1.37782010
58MP0004381_abnormal_hair_follicle1.37383516
59MP0009384_cardiac_valve_regurgitation1.36280527
60MP0003436_decreased_susceptibility_to1.35389620
61MP0002882_abnormal_neuron_morphology1.33753669
62MP0000678_abnormal_parathyroid_gland1.33113500
63MP0002066_abnormal_motor_capabilities/c1.32862750
64MP0003091_abnormal_cell_migration1.30980383
65MP0003633_abnormal_nervous_system1.29542831
66MP0003183_abnormal_peptide_metabolism1.29298900
67MP0002933_joint_inflammation1.27305381
68MP0000013_abnormal_adipose_tissue1.25902412
69MP0000920_abnormal_myelination1.17189441
70MP0001502_abnormal_circadian_rhythm1.15518477
71MP0005375_adipose_tissue_phenotype1.15352887
72MP0005666_abnormal_adipose_tissue1.14581830
73MP0004947_skin_inflammation1.13207600
74MP0003300_gastrointestinal_ulcer1.11984219
75MP0002152_abnormal_brain_morphology1.11680905
76MP0006276_abnormal_autonomic_nervous1.09063365
77MP0003075_altered_response_to1.04899920
78MP0010386_abnormal_urinary_bladder1.03716189
79MP0002069_abnormal_eating/drinking_beha1.03684352
80MP0000751_myopathy1.02850986
81MP0000733_abnormal_muscle_development1.01971020
82MP0003631_nervous_system_phenotype1.01931106
83MP0003453_abnormal_keratinocyte_physiol1.00633633
84MP0003172_abnormal_lysosome_physiology0.96357234
85MP0001177_atelectasis0.95065147
86MP0004043_abnormal_pH_regulation0.92167901
87MP0010234_abnormal_vibrissa_follicle0.91468142
88MP0001529_abnormal_vocalization0.90687794
89MP0005257_abnormal_intraocular_pressure0.90638721
90MP0002998_abnormal_bone_remodeling0.89038690
91MP0004185_abnormal_adipocyte_glucose0.88764820
92MP0004085_abnormal_heartbeat0.88233469
93MP0005499_abnormal_olfactory_system0.85650527
94MP0005394_taste/olfaction_phenotype0.85650527
95MP0000767_abnormal_smooth_muscle0.85226714
96MP0005623_abnormal_meninges_morphology0.85140696
97MP0004233_abnormal_muscle_weight0.83406519
98MP0008872_abnormal_physiological_respon0.83359882
99MP0005535_abnormal_body_temperature0.83237563
100MP0000566_synostosis0.82809307
101MP0008874_decreased_physiological_sensi0.82739949
102MP0005377_hearing/vestibular/ear_phenot0.80844871
103MP0003878_abnormal_ear_physiology0.80844871
104MP0002234_abnormal_pharynx_morphology0.80329699
105MP0000631_abnormal_neuroendocrine_gland0.78307499
106MP0003137_abnormal_impulse_conducting0.77301907
107MP0003634_abnormal_glial_cell0.75861971
108MP0000681_abnormal_thyroid_gland0.75129220
109MP0003566_abnormal_cell_adhesion0.74571607
110MP0006138_congestive_heart_failure0.74475309
111MP0002229_neurodegeneration0.74359503
112MP0003690_abnormal_glial_cell0.72158526
113MP0005167_abnormal_blood-brain_barrier0.71910917
114MP0001299_abnormal_eye_distance/0.71135904
115MP0001905_abnormal_dopamine_level0.69490386
116MP0004142_abnormal_muscle_tone0.69249913
117MP0002090_abnormal_vision0.68213912
118MP0002653_abnormal_ependyma_morphology0.67411136
119MP0001485_abnormal_pinna_reflex0.66999359
120MP0000534_abnormal_ureter_morphology0.66265466
121MP0002116_abnormal_craniofacial_bone0.65576432
122MP0002896_abnormal_bone_mineralization0.65522796
123MP0003632_abnormal_nervous_system0.65285866
124MP0005670_abnormal_white_adipose0.65020323
125MP0000537_abnormal_urethra_morphology0.64144784
126MP0005166_decreased_susceptibility_to0.63752263
127MP0003861_abnormal_nervous_system0.63620885
128MP0008438_abnormal_cutaneous_collagen0.63305402
129MP0002638_abnormal_pupillary_reflex0.63193137
130MP0000747_muscle_weakness0.63148244
131MP0002089_abnormal_postnatal_growth/wei0.62869114
132MP0001963_abnormal_hearing_physiology0.62750226
133MP0003763_abnormal_thymus_physiology0.62705104
134MP0001664_abnormal_digestion0.62220190
135MP0004130_abnormal_muscle_cell0.60966370
136MP0003045_fibrosis0.59186699
137MP0010769_abnormal_survival0.57550729
138MP0002752_abnormal_somatic_nervous0.57270486
139MP0000003_abnormal_adipose_tissue0.56270743
140MP0001765_abnormal_ion_homeostasis0.56151809
141MP0004510_myositis0.55688165
142MP0000604_amyloidosis0.54835102
143MP0010770_preweaning_lethality0.54554437
144MP0002082_postnatal_lethality0.54554437
145MP0003121_genomic_imprinting0.53772938

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.80020201
2Myokymia (HP:0002411)6.50842550
3Visual hallucinations (HP:0002367)5.39164349
4Focal seizures (HP:0007359)5.24130243
5Broad face (HP:0000283)3.78493691
6Epileptic encephalopathy (HP:0200134)3.74875037
7Absence seizures (HP:0002121)3.64397815
8Action tremor (HP:0002345)3.49600775
9Ankle clonus (HP:0011448)3.45998047
10Febrile seizures (HP:0002373)3.37602260
11Generalized tonic-clonic seizures (HP:0002069)3.36964263
12Progressive cerebellar ataxia (HP:0002073)3.36569250
13Abnormality of the lower motor neuron (HP:0002366)3.33748784
14Cerebral aneurysm (HP:0004944)3.32462141
15Supranuclear gaze palsy (HP:0000605)3.23844213
16Depression (HP:0000716)3.23185354
17Poor eye contact (HP:0000817)3.20812661
18Papilledema (HP:0001085)3.20416365
19Dialeptic seizures (HP:0011146)3.15418900
20Atonic seizures (HP:0010819)3.15336827
21Impaired vibration sensation in the lower limbs (HP:0002166)3.10754986
22Thin bony cortex (HP:0002753)3.05810258
23Postural instability (HP:0002172)3.03791900
24J-shaped sella turcica (HP:0002680)2.97999328
25Urinary bladder sphincter dysfunction (HP:0002839)2.97960479
26Torticollis (HP:0000473)2.97008989
27Impaired social interactions (HP:0000735)2.93677065
28Abnormal social behavior (HP:0012433)2.93677065
29Dysdiadochokinesis (HP:0002075)2.86794306
30Abnormal eating behavior (HP:0100738)2.84710054
31Genetic anticipation (HP:0003743)2.81249997
32Cervical subluxation (HP:0003308)2.77754393
33Focal dystonia (HP:0004373)2.69415500
34Broad-based gait (HP:0002136)2.67900918
35Hemiplegia (HP:0002301)2.65666078
36Amblyopia (HP:0000646)2.64988216
37Insomnia (HP:0100785)2.62592453
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.61682300
39Urinary urgency (HP:0000012)2.58798820
40Gaze-evoked nystagmus (HP:0000640)2.58588754
41Shallow orbits (HP:0000586)2.57803135
42Anxiety (HP:0000739)2.56936275
43Stridor (HP:0010307)2.56732068
44Annular pancreas (HP:0001734)2.56378180
45Impaired smooth pursuit (HP:0007772)2.53269914
46Pointed chin (HP:0000307)2.53030859
47Mutism (HP:0002300)2.52093260
48Lymphangioma (HP:0100764)2.51367184
49Ventricular fibrillation (HP:0001663)2.48603178
50Dysmetric saccades (HP:0000641)2.47508466
51Dysmetria (HP:0001310)2.44450814
52Truncal ataxia (HP:0002078)2.43376086
53Dysostosis multiplex (HP:0000943)2.42621920
54Bundle branch block (HP:0011710)2.41906144
55Craniofacial dystonia (HP:0012179)2.39590065
56Nuclear cataract (HP:0100018)2.33960165
57Bradykinesia (HP:0002067)2.30256702
58Spastic gait (HP:0002064)2.29342396
59Mucopolysacchariduria (HP:0008155)2.28903157
60Urinary glycosaminoglycan excretion (HP:0003541)2.28903157
61Mitral regurgitation (HP:0001653)2.28508254
62Drooling (HP:0002307)2.27391915
63Excessive salivation (HP:0003781)2.27391915
64Hemiparesis (HP:0001269)2.25773095
65Protrusio acetabuli (HP:0003179)2.25425616
66Stereotypic behavior (HP:0000733)2.24271656
67Hypoventilation (HP:0002791)2.24228792
68Epileptiform EEG discharges (HP:0011182)2.20840880
69Obstructive sleep apnea (HP:0002870)2.20058543
70EEG with generalized epileptiform discharges (HP:0011198)2.19585697
71Megalencephaly (HP:0001355)2.19355414
72Agitation (HP:0000713)2.18211724
73Abnormality of ocular smooth pursuit (HP:0000617)2.18139645
74Abnormality of polysaccharide metabolism (HP:0011012)2.17541592
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17541592
76Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17541592
77Hypsarrhythmia (HP:0002521)2.16563913
78Intention tremor (HP:0002080)2.15086102
79Lower limb amyotrophy (HP:0007210)2.14245007
80Abnormality of the fingertips (HP:0001211)2.13391233
81Failure to thrive in infancy (HP:0001531)2.12307401
82Biconcave vertebral bodies (HP:0004586)2.11170946
83Neoplasm of the heart (HP:0100544)2.10916474
84Resting tremor (HP:0002322)2.10804861
85Deformed sella turcica (HP:0002681)2.09914158
86Hyperacusis (HP:0010780)2.09861822
87Broad metatarsal (HP:0001783)2.09672610
88Distal lower limb amyotrophy (HP:0008944)2.08777656
89Ankyloglossia (HP:0010296)2.08619446
90Impaired vibratory sensation (HP:0002495)2.06700206
91Cerebral inclusion bodies (HP:0100314)2.04577136
92Elfin facies (HP:0004428)2.03851714
93Atelectasis (HP:0100750)2.01944755
94Flat acetabular roof (HP:0003180)1.99909775
95Germ cell neoplasia (HP:0100728)1.99477042
96Abnormal EKG (HP:0003115)1.98359309
97Lower limb muscle weakness (HP:0007340)1.97904917
98Polyphagia (HP:0002591)1.97887218
99Limb dystonia (HP:0002451)1.96732097
100Spinal canal stenosis (HP:0003416)1.95490608
101Macroorchidism (HP:0000053)1.90342556
102Aneurysm (HP:0002617)1.90322482
103Clonus (HP:0002169)1.87545615
104Hypercortisolism (HP:0001578)1.87286513
105Precocious puberty (HP:0000826)1.86944034
106Status epilepticus (HP:0002133)1.85735144
107Neurofibrillary tangles (HP:0002185)1.85709066
108Interstitial pulmonary disease (HP:0006530)1.85513955
109Joint stiffness (HP:0001387)1.85317582
110Aortic regurgitation (HP:0001659)1.84897196
111Rapidly progressive (HP:0003678)1.84207814
112Sleep apnea (HP:0010535)1.82863213
113Hyperventilation (HP:0002883)1.82838390
114Amyotrophic lateral sclerosis (HP:0007354)1.81779525
115Ulnar bowing (HP:0003031)1.80871315
116Prolonged QT interval (HP:0001657)1.80672923
117Aplasia involving bones of the upper limbs (HP:0009823)1.80576904
118Aplasia of the phalanges of the hand (HP:0009802)1.80576904
119Aplasia involving bones of the extremities (HP:0009825)1.80576904
120Diplopia (HP:0000651)1.80395777
121Abnormality of binocular vision (HP:0011514)1.80395777
122Onion bulb formation (HP:0003383)1.79889283
123Bronchomalacia (HP:0002780)1.78960561
124Distal upper limb amyotrophy (HP:0007149)1.78839888
125Upper limb amyotrophy (HP:0009129)1.78839888
126Hand muscle atrophy (HP:0009130)1.78137720
127Fetal akinesia sequence (HP:0001989)1.77853853
128Lower limb asymmetry (HP:0100559)1.77209498
129Neuronal loss in central nervous system (HP:0002529)1.77059583
130Peripheral hypomyelination (HP:0007182)1.77021091
131Generalized myoclonic seizures (HP:0002123)1.77001681
132Metaphyseal cupping (HP:0003021)1.76589483
133Insidious onset (HP:0003587)1.74409084
134Termporal pattern (HP:0011008)1.74409084
135Difficulty climbing stairs (HP:0003551)1.72579259
136Turricephaly (HP:0000262)1.71803446
137Abnormality of the aortic arch (HP:0012303)1.70821209
138Visceral angiomatosis (HP:0100761)1.69362570
139Intellectual disability, profound (HP:0002187)1.68753589
140Vitreoretinal degeneration (HP:0000655)1.68176996
141Arterial tortuosity (HP:0005116)1.66478401
142Increased connective tissue (HP:0009025)1.66376040
143Colitis (HP:0002583)1.66013500
144Bell-shaped thorax (HP:0001591)1.65130457
145Abnormality of the thoracic spine (HP:0100711)1.63199237
146Asymmetry of the thorax (HP:0001555)1.63151217
147Disproportionate tall stature (HP:0001519)1.61901156
148Hyperthyroidism (HP:0000836)1.61131241
149Bladder diverticulum (HP:0000015)1.60923918
150Long palpebral fissure (HP:0000637)1.60566864
151Abnormality of the radial head (HP:0003995)1.60378953
152Supernumerary nipples (HP:0002558)1.59264771
153Dislocated radial head (HP:0003083)1.59218739
154Thin ribs (HP:0000883)1.57063961
155Asymmetric septal hypertrophy (HP:0001670)1.56132204
156Hypoplastic ischia (HP:0003175)1.55575682
157Hyperparathyroidism (HP:0000843)1.54722458
158Emphysema (HP:0002097)1.54546290
159Atrophic scars (HP:0001075)1.52670919
160Bowel incontinence (HP:0002607)1.51482651
161Difficulty running (HP:0009046)1.50024936
162Vascular tortuosity (HP:0004948)1.49687785
163Renovascular hypertension (HP:0100817)1.48877845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.24261641
2NTRK34.22187845
3MAP3K93.95187925
4MARK13.11906239
5PRKD33.09426495
6SIK12.74232072
7DAPK22.71943443
8MINK12.57079283
9PAK62.55883518
10MAP3K42.45697510
11NTRK22.30457026
12KSR22.18792113
13CAMKK12.10958077
14EEF2K2.00577420
15NTRK11.82185002
16FGFR41.80936616
17ERN11.79906421
18MAP2K71.77055632
19KSR11.74465641
20STK381.72559832
21MAP3K21.62116699
22SMG11.61781978
23TYRO31.60337035
24MAP2K41.57622021
25TAOK11.56017068
26CDK51.51911194
27MAPK151.44131370
28PRPF4B1.44054324
29DAPK11.39060969
30RIPK11.31638892
31CDK121.31020850
32MAP3K121.28308002
33SIK21.27879041
34LATS21.21723627
35UHMK11.21013959
36MAP2K31.18028724
37TNIK1.17090408
38MAP4K11.15176336
39TRIB31.12315264
40PRKCH1.11003589
41PDGFRA1.09120302
42ALK1.06909137
43MAPK121.06492844
44TTN1.05335221
45MAP3K61.03460929
46EPHB11.03363454
47PRKCG1.03251526
48MAPK131.01693705
49GRK51.01154439
50CAMK10.98977323
51PHKG20.98670769
52PHKG10.98670769
53MTOR0.98621312
54MAP2K60.98565316
55RET0.97651033
56MAP3K110.97573902
57PAK30.95440080
58RIPK40.94984543
59LMTK20.94709009
60STK110.94151911
61FGFR30.93529584
62HIPK20.91837307
63CDC42BPA0.91797621
64MARK20.91226278
65MAP3K100.90127441
66PTK60.89525539
67FES0.87251492
68MAP3K130.86176495
69CDK180.85365268
70DDR20.84870774
71CAMK1G0.84468523
72CDK150.83304610
73ZAP700.83248117
74CAMKK20.82918675
75PLK20.78567213
76PDGFRB0.78295293
77SGK2230.78002440
78SGK4940.78002440
79MAP3K10.76232747
80RPS6KC10.76223652
81RPS6KL10.76223652
82CAMK1D0.75830672
83ERBB20.74410882
84SGK30.74241058
85ARAF0.74105132
86CDK140.73700585
87NEK10.73240485
88SGK10.72930975
89TESK10.72272110
90DMPK0.72257205
91CDK11A0.71661096
92PTK20.69552354
93CAMK2A0.67836440
94SGK20.67028781
95RAF10.65786840
96PDK10.65324211
97PKN20.65169561
98PRKD20.64889582
99MAPK70.63741840
100PDPK10.62882772
101SCYL20.62458779
102JAK10.62353867
103FER0.61912967
104WNK30.61325308
105PINK10.61089853
106DYRK1A0.60838500
107MAP2K20.58834521
108TYK20.58423137
109CAMK40.58210651
110RPS6KA60.57452878
111EPHA20.56942651
112ICK0.56516128
113MAP3K70.55838540
114RPS6KA20.55664864
115TBK10.55292581
116DYRK1B0.55252187
117CSNK1G20.54632387
118RPS6KA30.54388520
119TNK20.51036958
120PRKCZ0.51011013
121MAPK80.50384702
122PTK2B0.50346162
123MAPK100.47816499
124PRKD10.46394183
125PNCK0.46144771
126CAMK2B0.46103223
127GRK60.45962104
128FYN0.44732996
129MAP2K10.42539613
130BMX0.42053497
131FGFR20.41996147
132BRSK10.41290470
133CDK190.41057847
134MAP3K30.40115621
135WNK10.39868095
136CSK0.39717848
137PRKCE0.38661289
138NEK60.37745403
139TAOK20.35275127
140DAPK30.34016726
141SIK30.33866451

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.00719657
2Nicotine addiction_Homo sapiens_hsa050332.93018187
3Olfactory transduction_Homo sapiens_hsa047402.80727447
4Circadian entrainment_Homo sapiens_hsa047132.54768406
5GABAergic synapse_Homo sapiens_hsa047272.46920841
6Long-term potentiation_Homo sapiens_hsa047202.43864877
7Glutamatergic synapse_Homo sapiens_hsa047242.36357607
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32781298
9Amphetamine addiction_Homo sapiens_hsa050312.32693694
10Morphine addiction_Homo sapiens_hsa050322.30362403
11Insulin secretion_Homo sapiens_hsa049112.25409086
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23603048
13Dopaminergic synapse_Homo sapiens_hsa047282.03543032
14Other glycan degradation_Homo sapiens_hsa005112.01541377
15Salivary secretion_Homo sapiens_hsa049701.96163640
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91867274
17Gastric acid secretion_Homo sapiens_hsa049711.90826415
18Cholinergic synapse_Homo sapiens_hsa047251.85566245
19Cocaine addiction_Homo sapiens_hsa050301.82974004
20Notch signaling pathway_Homo sapiens_hsa043301.82200845
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71025172
22Oxytocin signaling pathway_Homo sapiens_hsa049211.58965831
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53513038
24Renin secretion_Homo sapiens_hsa049241.52800008
25Type II diabetes mellitus_Homo sapiens_hsa049301.49600605
26Taste transduction_Homo sapiens_hsa047421.48651485
27Nitrogen metabolism_Homo sapiens_hsa009101.46967715
28GnRH signaling pathway_Homo sapiens_hsa049121.46870919
29Calcium signaling pathway_Homo sapiens_hsa040201.42937791
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39833987
31Long-term depression_Homo sapiens_hsa047301.34888051
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.34163897
33Gap junction_Homo sapiens_hsa045401.33977785
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33627917
35Acute myeloid leukemia_Homo sapiens_hsa052211.29830553
36Serotonergic synapse_Homo sapiens_hsa047261.29441883
37cAMP signaling pathway_Homo sapiens_hsa040241.25517328
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25045715
39Glioma_Homo sapiens_hsa052141.25041251
40Estrogen signaling pathway_Homo sapiens_hsa049151.24269740
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23817296
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21976486
43Chronic myeloid leukemia_Homo sapiens_hsa052201.21361965
44ErbB signaling pathway_Homo sapiens_hsa040121.14824290
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13889590
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12761068
47B cell receptor signaling pathway_Homo sapiens_hsa046621.12003881
48Axon guidance_Homo sapiens_hsa043601.10536304
49Melanogenesis_Homo sapiens_hsa049161.10097530
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07540472
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05655939
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94331029
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.93569826
54Osteoclast differentiation_Homo sapiens_hsa043800.92348450
55Collecting duct acid secretion_Homo sapiens_hsa049660.91590199
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.90828630
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90248265
58T cell receptor signaling pathway_Homo sapiens_hsa046600.89328441
59Thyroid hormone synthesis_Homo sapiens_hsa049180.88819394
60Focal adhesion_Homo sapiens_hsa045100.88262915
61mTOR signaling pathway_Homo sapiens_hsa041500.87448593
62Dilated cardiomyopathy_Homo sapiens_hsa054140.86981832
63Dorso-ventral axis formation_Homo sapiens_hsa043200.86285637
64Pancreatic secretion_Homo sapiens_hsa049720.85505745
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83740612
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83217462
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81433074
68Oocyte meiosis_Homo sapiens_hsa041140.80947940
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78700729
70Endometrial cancer_Homo sapiens_hsa052130.77892622
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.77102192
72Choline metabolism in cancer_Homo sapiens_hsa052310.76241050
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.76030805
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75707119
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.75666313
76Vibrio cholerae infection_Homo sapiens_hsa051100.75405567
77Pancreatic cancer_Homo sapiens_hsa052120.74770019
78MAPK signaling pathway_Homo sapiens_hsa040100.74761024
79Glucagon signaling pathway_Homo sapiens_hsa049220.74060473
80VEGF signaling pathway_Homo sapiens_hsa043700.72915949
81Amoebiasis_Homo sapiens_hsa051460.71779003
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70672029
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70388749
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70140504
85Insulin resistance_Homo sapiens_hsa049310.69883357
86Bile secretion_Homo sapiens_hsa049760.68163975
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67514398
88Rap1 signaling pathway_Homo sapiens_hsa040150.67508133
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67266443
90TNF signaling pathway_Homo sapiens_hsa046680.65261872
91Platelet activation_Homo sapiens_hsa046110.65047741
92Hepatitis C_Homo sapiens_hsa051600.64718495
93Insulin signaling pathway_Homo sapiens_hsa049100.64714792
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.63731706
95Non-small cell lung cancer_Homo sapiens_hsa052230.61295357
96ABC transporters_Homo sapiens_hsa020100.61097874
97Proteoglycans in cancer_Homo sapiens_hsa052050.60486632
98Ras signaling pathway_Homo sapiens_hsa040140.59942084
99FoxO signaling pathway_Homo sapiens_hsa040680.59908721
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59737589
101ECM-receptor interaction_Homo sapiens_hsa045120.57969399
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56669819
103Cardiac muscle contraction_Homo sapiens_hsa042600.56477961
104Type I diabetes mellitus_Homo sapiens_hsa049400.55835937
105Endocytosis_Homo sapiens_hsa041440.55586341
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55453044
107Inositol phosphate metabolism_Homo sapiens_hsa005620.55237728
108Wnt signaling pathway_Homo sapiens_hsa043100.54221703
109Prion diseases_Homo sapiens_hsa050200.53180902
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52167185
111Circadian rhythm_Homo sapiens_hsa047100.50996022
112Renal cell carcinoma_Homo sapiens_hsa052110.47068948
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46674858
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45773298
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.44889970
116Alcoholism_Homo sapiens_hsa050340.42372336
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41920116
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40905729
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.40235558
120Prolactin signaling pathway_Homo sapiens_hsa049170.37876847
121Colorectal cancer_Homo sapiens_hsa052100.35969238
122Ovarian steroidogenesis_Homo sapiens_hsa049130.35776681
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34936935
124Chemokine signaling pathway_Homo sapiens_hsa040620.33976259
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33822250
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32528976
127Arginine biosynthesis_Homo sapiens_hsa002200.32299147
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30556243
129AMPK signaling pathway_Homo sapiens_hsa041520.29633797

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